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Effect of castration on penile erection in the dog
Author(s) -
Creed Kate E.
Publication year - 1989
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.1930080609
Subject(s) - medicine , castration , phenylephrine , stimulation , sexual stimulation , erectile tissue , penis , testosterone (patch) , contraction (grammar) , erectile dysfunction , urology , endocrinology , blood pressure , surgery , hormone
The reduction in sexual activity in hypogonadal men is at least partially due to a decrease in sexual interest, but it may also involve peripheral mechanisms. In the present experiments, the effects of castration on penile erection in dogs was investigated. The pressure within the corpus cavernosum was measured in intact anaesthetized dogs and in dogs castrated 2 weeks or more than 6 months previously. It was found that there was no significant difference between intact and castrated dogs in the magnitude or time course of increase in corpus cavernosal pressure induced by pelvic nerve stimulation or in the inhibitory effects of simultaneous stimulation of the sympathetic chain. Furthermore, the mean ED 50 value for contraction to phenylephrine of isolated strips of erectile tissue from the corpus cavernosum was not significantly different between groups. This suggests that the mechanism of penile erection is not affected by reducing the levels of testosterone.