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Experimental models of reflex contractile activity in the rabbit bladder
Author(s) -
Kitada Shinichiro,
Kato Kumiko,
Wein Alan J.,
Levin Robert M.
Publication year - 1989
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.1930080313
Subject(s) - reflex , hexamethonium , medicine , atropine , distension , triceps reflex , stimulation , urinary bladder , oculocardiac reflex , cholinergic , contraction (grammar) , constriction , anesthesia , anatomy , withdrawal reflex
Abstract We were able to produce two highly reproducible experimental models (in the rabbit) that demonstrated a high degree of reflex bladder contractile activity. In one model, a somatovesical reflex was induced by touching or pinching the perineal area. This reflex may be organized through a neurogenic reflex at the spinal level. In another model, rhythmic bladder contractions were produced by distal urethral constriction in the absence of bladder distension. These rhythmic contractions were thought to be due to a supraspinal reflex. In both types of contractile reflexes, intravenous administration of hexamethonium inhibited the reflex contractile activity virtually completely, intravenous atropine inhibited over 90% of the induced contractile activity, thus suggesting that these contractions were mediated reflexly through cholinergic stimulation. These two models of reflex bladder contractions should be useful for the study of hyperreflexic bladders.