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Micturition‐facilitating mechanism in benign prostatic hypertrophy: A theory
Author(s) -
Cucchi A.
Publication year - 1987
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.1930060605
Subject(s) - medicine , urination , cystometry , prostatism , urology , muscle hypertrophy , urethra , cystoscopy , prostatic urethra , urinary bladder , prostate , urinary system , prostate disease , cancer
Forty males aged 46–82 years (mean, 65 years) with bladder outflow obstruction due to benign prostatic hypertrophy were chosen among a group referred for prostatism. They were assessed by means of symptom analysis, rectal examination, intravenous urography and/or cystoscopy, and urodynamic testing (medium‐fill water cystometry and pressure flow study). Only those patients were considered who had compensated bladders with no severe trabeculation. A significant correlation was found in this series between urethral resistance and opening time (r = −.41, p < .01), the best fit being a negative exponential relationship (the higher the degree of obstruction, the lesser the time needed to reach the threshold pressure at which flow begins). This was supposed to describe a real micturition‐facilitating mechanism, which might be explained by abnormal activation of a nerve pathway relaying through the spinal cord between the proximal urethra and detrusor muscle. Such a mechanism would be valid for those proximally obstructed bladders with mild to moderate detrusor collagenosis.