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Urinary bladder reformation: Regeneration or dilatation?
Author(s) -
Gasser Thomas C.,
Larsen Erik H.,
England Douglas M.,
Graversen Peder H.,
Dørflinger Torben,
Madsen Paul O.,
Bruskewitz Reginald C.
Publication year - 1987
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.1930060210
Subject(s) - trigone of urinary bladder , medicine , cystectomy , regeneration (biology) , urinary bladder , surgery , detrusor muscle , neck of urinary bladder , urology , anatomy , urinary system , urinary diversion , urinary incontinence , biology , bladder cancer , cancer , microbiology and biotechnology
In an earlier study, urinary bladder regeneration was investigated. For that purpose, 15 dogs were subjected to total or subtotal cystectomy, and a silicone rubber prosthesis was nestled in the trigone and covered with polyglycolic acid mesh. After 3–5 months, a newly formed urinary reservoir was found in six dogs. Since transitional cell epithelium and smooth muscle were identified in the wall of the reservoir, it was concluded that bladder regeneration had probably occurred. However, the possibility of distention of the trigone to form the new cavity could not be ruled out. Therefore, six additional dogs were subjected to subtotal cystectomy, ileal loop, and temporary artificial bladder implantation. The edges of the bladder resection were marked with nonabsorbable sutures. In three fully evaluable dogs a urinary cavity was identified. This was mainly formed by trigonal distention. While the epithelium had regrown over a small area of fibrous tissue found at the dome of the reservoir, no smooth muscle regeneration was found. It is concluded that the new reservoir was formed by trigonal dilatation rather than by regeneration.