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Effect of opiate dependence on erectile function in primates
Author(s) -
Levin Robert M.,
Strong George,
Brenman Henry,
Hayes Lynn,
Memberg William,
O'Brien C. P.,
Ternes Joe W.,
Wein Alan
Publication year - 1986
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.1930050406
Subject(s) - opiate , medicine , morphine , opiate receptors , stimulation , erectile function , anesthesia , erectile dysfunction , (+) naloxone , opioid , receptor
Thirteen nonhuman primates (Macaca mulatta and Madada fascicularis) were placed and maintained on opiates (six on morphine, seven on hydromorphone). Eight nondependent opiate naive primates were used as controls. Noninvasive transrectal electronic stimulation using a Biosonics MEGS Registered trademark and devices by Biosonics, Inc. Philadelphia, Patents pending. unit was employed to produce erection in all primates. This device has been previously demonstrated to produce consistant, full erections in the species of monkeys employed in these studies. The opiate‐dependent monkeys were tested both after being maintained on the opiates for 150 days, and following a 30‐day washout period (opiate free). The results clearly demonstrate that opiate dependence did not alter the erectile response to rectal stimulation, thus the dependence did not negatively affect the neural or cardiovascular components of the erectile system. Analysis of the results demonstrated although there were no difference between species, there was a significant acquisition effect for the transrectal stimulation procedure.