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Neural control of the urinary bladder: Possible relationship between peptidergic inhibitory mechanisms and detrusor instability
Author(s) -
De Groat William C.,
Kawatani Masahito
Publication year - 1985
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.1930040405
Subject(s) - medicine , efferent , neuroscience , inhibitory postsynaptic potential , urination , urinary bladder , afferent , neuropeptide , neuromodulation , urinary system , reflex , central nervous system , urology , receptor , psychology
This paper provides a brief review of the organization of the neural mechanisms controlling micturition. The role of neuropeptides in peripheral afferent and efferent pathways and in the central reflex mechanisms is discussed. A major focus of the paper is on the inhibitory functions of spinal and supraspinal enkephalinergic systems in the control of bladder capacity and bladder stability. Pharmacological studies indicate that drug‐induced changes in enkephalinergic mechanisms can elicit marked alterations in bladder function. Similar changes in transmitter mechanisms may occur following neural injury or disease and therefore be involved in the development of neurogenic disorders of the lower urinary tract.