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Effect of metoclopramide on ejaculatory threshold in a group of premature ejaculators
Author(s) -
Wabrek Alan J.
Publication year - 1984
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.1930030304
Subject(s) - premature ejaculation , metoclopramide , medicine , ejaculation , placebo , crossover study , anesthesia , etiology , psychology , vomiting , alternative medicine , pathology , psychoanalysis
The exact etiology of premature ejaculation is not known. Recent data using rats has demonstrated that dopamine agonists can lower ejaculatory thresholds while pretreatment with substituted benzamides will block that effect. Metoclopramide, the only drug in the group available in the United States, and a placebo were given to 12 premature ejaculators in a double‐blind crossover fashion. Couples had intercourse on Wednesdays and Saturdays for four weeks. Ejaculatory latencies were recorded separately by husbands and wives on a 1–5 scale. There was no statistical difference in perception of ejaculatory latency between metoclopramide‐ and placebo‐treated coiti although the P values for the wives' perception was.067. An added observation was that approximately 80% of premature ejaculators had palmar hyperhidrosis. It is conjectured that early ejaculation and palmar hidrosis are manifestations of sympathetically mediated “overreactivity”.