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Effect of lsoproterenol and EGTA on the volume‐pressure relationship of the in vitro whole bladder preparation
Author(s) -
Levin Robert M.,
Goldman Michele,
Wein Alan J.
Publication year - 1984
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.1930030207
Subject(s) - medicine , egta , urinary bladder , isometric exercise , urology , detrusor muscle , compliance (psychology) , volume (thermodynamics) , in vitro , chemistry , calcium , biochemistry , psychology , social psychology , physics , quantum mechanics
In a previous study comparing the pharmacological response of smooth muscle strips isolated from rabbit urinary bladder with the response of the whole bladder preparation, we observed that although isoproterenol stimulated a marked decrease in isometric tension in the muscle strips, isoproterenol only slightly decreased intravesical pressure (whole bladder preparation). We have recently modified our whole bladder system so that we can now quantitativelydetermine the effect of drugs on bladder volume at constant pressure as well as onintravesical pressure at constant volume. Using this system we have reinvestigated theeffect of isoproterenol and have demonstrated that although isoproterenol has only a slighteffect on intravesical pressure, this minor effect on pressure resulted in a marked increasein whole bladder volume, and a corresponding increase in cystometric compliance.