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Prostaglandins in lower urinary tract
Author(s) -
Pavlakis Aristidis J.,
Siroky Mike B.,
Leslie Crystal A.,
Krane Robert J.
Publication year - 1983
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.1930020203
Subject(s) - medicine , contraction (grammar) , urinary system , stimulation , prostaglandin , smooth muscle , detrusor muscle , urinary bladder , urology , prostaglandin e , endocrinology
The search for noncholinergic, nonadrenergic neurotransmitters in the lower urinary tract has recently focused on the prostaglandins (PG). Prostaglandin E 2 (PGE 2 ) and, to a lesser degree, prostaglandin F Zα (PGF zα ), are produced by the bladder in response to mechanical and nerve stimulation. In vitro stimulation of detrusor smooth muscle, using the same two compounds, produces a slow, prolonged contraction which is independent of nervous activity. In contrast, in urethral smooth muscle PGF 2α causes contraction while PGE 2 causes relaxation. Clinically, intravesical or intravenous administration of PGE 2 or PGF 2α may produce improved bladder tone or uninhibited contraction. Similarly, inhibitors of PG synthesis may produce improvement of unstable bladder.