Premium
The effects of acute overdistention of the rabbit urinary bladder
Author(s) -
Levin Robert M.,
Staskin David R.,
Wein Alan J.
Publication year - 1983
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.1930020109
Subject(s) - medicine , methoxamine , bethanechol , adenosine triphosphate , urinary bladder , urinary system , urology , endocrinology , agonist , receptor , muscarinic acetylcholine receptor
The effects of in vivo acute overdistention on both the metabolic state and the in vitro contractile responses of the rabbit urinary bladder were studied. Intracellular adenosine triphosphate (ATP) was used as an indicator of the metabolic states. The responses of isolated strips of bladder body and base to bethanechol, methoxamine, and isoproterenol were used to assess pharmacologic response. The results of acute overdistention for one hour can be summarized as follows: (1) There was no significant decrease in the intracel Mar stores of high‐energy phosphate (ATP). (2) The cholinergic‐induced contractile response of the bladder body was significantly decreased. After one week of recovery, the cholinergic response returned to control levels. (3) There was a moderate shift in the dose‐response of the bladder base to methoxarnine. After one week of recovery, the response to methoxamine returned to control levels. It is concluded that overdistention produces an immediate dysfunction in the contractile system of the bladder that is not secondary to a reduction in intracellular ATP and is reversible within one week following overdistention.