Premium
The muscarinic cholinergic binding kinetics of the human urinary bladder
Author(s) -
Levin Robert M.,
Staskin David R.,
Wein Alan J.
Publication year - 1982
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.1930010215
Subject(s) - quinuclidinyl benzilate , cholinergic , muscarinic acetylcholine receptor , medicine , receptor–ligand kinetics , kinetics , radioligand , urinary bladder , receptor , endocrinology , pharmacology , physics , quantum mechanics
Determination of (1) the absolute number of cholinergic receptors, (2) the cholinergic binding kinetics, and (3) the direct antimuscarinic activity of a series of uropharmacologic agents was accomplished by radioligand binding techniques in tissue derived from human urinary bladder. The competition between 3 H‐quinuclidinyl benzilate ( 3 H‐QNB) binding and selective antagonists provided the first quantitative assessment of cholinergic receptor characteristics in the human bladder fundus and represents a potential method for assessing the antimuscarinic binding potential of uropharmacologic agents.