The muscarinic cholinergic binding kinetics of the human urinary bladder | Zendy

Levin Robert M. | Zendy; Staskin David R. | Zendy; Wein Alan J. | Zendy

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The muscarinic cholinergic binding kinetics of the human urinary bladder

Author(s) -

Levin Robert M.,

Staskin David R.,

Wein Alan J.

Publication year - 1982

Publication title -

neurourology and urodynamics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.918

H-Index - 90

eISSN - 1520-6777

pISSN - 0733-2467

DOI - 10.1002/nau.1930010215

Subject(s) - quinuclidinyl benzilate , cholinergic , muscarinic acetylcholine receptor , medicine , receptor–ligand kinetics , kinetics , radioligand , urinary bladder , receptor , endocrinology , pharmacology , physics , quantum mechanics

Determination of (1) the absolute number of cholinergic receptors, (2) the cholinergic binding kinetics, and (3) the direct antimuscarinic activity of a series of uropharmacologic agents was accomplished by radioligand binding techniques in tissue derived from human urinary bladder. The competition between 3 H‐quinuclidinyl benzilate ( 3 H‐QNB) binding and selective antagonists provided the first quantitative assessment of cholinergic receptor characteristics in the human bladder fundus and represents a potential method for assessing the antimuscarinic binding potential of uropharmacologic agents.

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