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Transient ischemic attack after electromotive drug administration for chronic non‐infectious cystitis: Report of two similar cases
Author(s) -
Hinkel Andreas,
Pannek Jürgen
Publication year - 2004
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.10157
Subject(s) - medicine , drug , anesthesia , irritation , drug administration , pharmacology , immunology
Electromotive drug administration (EMDA) is a new and promising approach for the treatment of chronic non‐infectious cystitis. In animal studies utilizing EMDA there was evidence for deep penetration of dyes into the muscular layers of the bladder wall. However, besides minor local irritation no systemic side effects have been reported after translation of EMDA into the clinical setting. Aims This article reports for the first time systemic neurological alterations after EMDA for chronic non‐infectious cystitis. Subjects and Methods Two male patients, aged 72 and 78 years, respectively, were readmitted to the emergency room within few hours after EMDA showing clinical signs of transient ischemic attacks (TIA). After clinical examination, both patients were observed. Results Under overnight observation without any specific therapy the symptoms vanished completely in both patients. Conclusions In older patients (>70 years of age) undergoing EMDA, cardiac and neurologic function should be monitored. The time of treatment during the first EMDA session should be limited to 15 or 20 min. Neurourol. Urodynam. 23:180–182, 2004. © 2004 Wiley‐Liss, Inc.