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Low‐rate nerve stimulation during regional ischemia in the diagnosis of muscle glycogenosis
Author(s) -
Lomonaco Mauro,
Milone Margherita,
Valente Enza Maria,
Padua Luca,
Tonali Pietro
Publication year - 1996
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880191204
Subject(s) - facilitation , ischemia , stimulation , depression (economics) , myasthenia gravis , medicine , neuromuscular transmission , anesthesia , median nerve , cardiology , psychology , surgery , neuroscience , economics , macroeconomics
Five patients with muscle glycogenoses (Gly), 30 normal subjects (NS), and 52 disease controls received 3 Hz repetitive stimulation of the ulnar nerve for 4 min (P‐LRNS) during regional ischemia and during normal circulation. During regional ischemia, the compound muscle action potential (CMAP) of NS showed 8.5% (SE: 1.0) facilitation after 1 min of P‐LRNS and 4.8 ± 1.5% facilitation after 4 min. Gly showed 8.1 ± 1.0% facilitation after 1 min of P‐LRNS but −58.6 ± 6.9% depression after 4 min of P‐LRNS. During normal circulation, in 18 NS and 4 Gly tested, the facilitation detected after 1 min of P‐LRNS was unchanged until the end of stimulation. Compared with the mean ± 2 SD of NS, individual values of CMAP depression were abnormal in all Gly patients already by the 3rd min of ischemic P‐LRNS. of disease controls, myasthenia gravis patients only showed a CMAP depression during ischemic P‐LRNS which was distinguishable from that detected in Gly, being mainly induced by neuromuscular transmission block. © 1996 John Wiley & Sons, Inc.