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Persistent increased threshold of electrical stimulation selective to motor nerve in multifocal motor neuropathy
Author(s) -
Yokota Takanori,
Saito Yukinobu,
Yuki Nobuhiro,
Tanaka Hiroaki
Publication year - 1996
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880190702
Subject(s) - motor nerve , stimulation , neuroscience , medicine , multifocal motor neuropathy , physical medicine and rehabilitation , psychology , mismatch negativity , electroencephalography
In multifocal motor neuropathy (MMN) the threshold of electrical stimulation showed a persistent, marked increase for the motor nerve which decreased after treatment with intravenous immunoglobulin or oral cyclophosphamide; whereas, the threshold was normal for the sensory nerve. This discrepancy of the thresholds for motor and sensory nerves indicates that the increased threshold for motor nerve is not caused by change in perineural capacitance, such as subperi‐ and endoneural endema or perineural thickening. Inching studies showed that the site of the elevated motor nerve threshold was closely associated with conduction slowing and block. For the cause of the increased threshold, therefore, we suppose the presence of a factor which interferes with reorganization of the nodal property in the remyelinative process or which directly blocks sodium channels where the blood–nerve barrier is impaired in MMN. © 1996 John Wiley & Sons, Inc.