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Clinicopathological features of MERRF
Author(s) -
Fukuhara Nobuyoshi
Publication year - 1995
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880181419
Subject(s) - pathological , pathology , medicine , muscle biopsy , stage (stratigraphy) , biopsy , biology , paleontology
Clinical features of MERRF are varied in terms of patterns and severity of symptoms at the early stage. The age of onset differs even in the same family. Occasionally, ragged‐red fibers are not found upon the muscle biopsy. Pathological features in some patients are very mild in comparison with their clinical symptoms; genetic analysis is needed for diagnosis. Unique clinical features in members of three families with MERRF are reported. © 1995 John Wiley & Sons, Inc.