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Conduction velocity distributions compared to fiber size distributions in normal human sural nerve
Author(s) -
van Veen Benno K.,
Schellens Ronald L. L. A.,
Stegeman Dick F.,
Schoonhoven Ruurd,
GabreëlsFesten Anneke A. W. M.
Publication year - 1995
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880181008
Subject(s) - histogram , sural nerve , nerve conduction velocity , inverse , anatomy , mathematics , amplitude , fiber , electrophysiology , statistics , physics , materials science , biology , medicine , geometry , optics , computer science , artificial intelligence , composite material , image (mathematics)
Compound action potentials (CAPs) were recorded from the sural nerve of healthy volunteers. A mathematical technique (inverse modeling) was used to compute conduction velocity (CV) histograms from the data. Results were compared to the morphology of age‐matched normal sural nerve biopsies. Coefficients of variation (CoVs) revealed the statistical relationship between morphological data (diameter histograms) and electrophysiological data (CV histograms and conventional CAP parameters). No differences were found for the thick fiber group when comparing the CoVs of the diameter histogram parameters with the corresponding CV histogram parameters. Apparently, the same inherent biological interindividual variability is encountered. The CoVs of the CVs of the CAP's main phases are in good agreement with the CoVs of the estimated mean velocity of the thick fiber group. Inverse modeling increases the reliability of the estimation of the number of active fibers as compared to direct CAP amplitude interpretation.© 1995 John Wiley & Sons, Inc.