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Amyloidosis causing a progressive myopathy
Author(s) -
Nadkarni Nitin,
Freimer Miriam,
Mendell Jerry R.
Publication year - 1995
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880180914
Subject(s) - amyloidosis , myopathy , amyloid (mycology) , inclusion body myositis , pathology , apposition , inclusion bodies , muscle weakness , myositis , medicine , anatomy , biology , biochemistry , escherichia coli , gene
A 62‐year‐old woman developed profound weakness secondary to a progressive myopathy associated with primary systemic amyloidosis. The characteristic apple‐green birefringent amyloid deposits were demonstrated surrounding individual muscle fibers in Congo red stained sections. Electron microscopy demonstrated amyloid filaments in close apposition to muscle fibers exhibiting excessive corrugations of the sarcolemmal membrane. The pathological features of progressive amyloid myopathy associated with primary systemic amyloidosis are distinct from the intracellular amyloid deposits characteristic of sporadic inclusion body myositis and inherited inclusion body myopathy. © 1995 John Wiley & Sons, Inc.