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Cerebrospinal fluid and serum from patients with inflammatory polyradiculoneuropathy have opposite effects on sodium channels
Author(s) -
Würz Axel,
Brinkmeier Heinrich,
Wollinsky Kurt H.,
Mehrkens HansH.,
Kornhuber Hans H.,
Rüdel Reinhardt
Publication year - 1995
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880180715
Subject(s) - cerebrospinal fluid , polyradiculoneuropathy , sodium channel , medicine , guillain barre syndrome , sodium , albumin , endocrinology , gastroenterology , anesthesia , chemistry , immunology , organic chemistry
The effects of cerebrospinal fluid (CSF) and serum from patients having Guillain–Barré syndrome (GBS) or chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) on voltage‐dependent Na + channels were compared. Bathing human myoballs in CSF substantially reduced their Na + currents (by >40% with 8 of 10 patients) elicited at 1 Hz under whole‐cell recording conditions. This was because, at the resting potential, more Na + channels were inactivated (left‐shift of the h ∞ curve). CSF from patients with other neurological diseases (OND) produces a similar, but smaller, effect. In contrast, serum samples from the same GBS and OND patients caused an increase of the Na + currents by reducing the number of Na + channels inactivated at the resting potential. This right‐shift of the h ∞ curve is in part explained by the effect of serum albumin. We confirm that the CSF of most GBS and CIDP patients contains factors inhibiting voltage‐dependent Na + currents. There is no indication that such factors are effective in the serum of these patients. © 1995 John Wiley & Sons, Inc.