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Anti‐gal‐C antibody in autoimmune neuropathies subsequent to mycoplasma infection
Author(s) -
Kusunoki Susumu,
Chiba Atsuro,
Hitoshi Seiji,
Takizawa Hajime,
Kanazawa Ichiro
Publication year - 1995
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880180407
Subject(s) - mycoplasma pneumoniae , galactocerebroside , immunology , antibody , pathogenesis , multifocal motor neuropathy , autoimmune disease , guillain barre syndrome , medicine , autoantibody , mycoplasma , autoimmunity , antigen , biology , microbiology and biotechnology , myelin , mismatch negativity , oligodendrocyte , central nervous system , pneumonia , electroencephalography , psychiatry
Four of 82 patients with Guillain‐Barré syndrome (GBS) and 1 of 12 with multifocal motor neuropathy (MMN), who previously had had Mycoplasma pneumoniae infections, had serum antibody to galactocerebroside (Gal‐C). Two patients with GBS without mycoplasma infection also had anti‐Gal‐C antibody, whereas none of the normal or the disease controls had it. As Gal‐C is a major glycolipid antigen in myelin, anti‐Gal‐C antibody may function in the pathogenesis of autoimmune demyelinative neuropathies. Mycoplasma pneumoniae appears to be an important preceding infectious agent in autoimmune neuropathies with anti‐Gal‐C antibody. © 1995 John Wiley & Sons, Inc.