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Early diagnosis of n ‐hexane–caused neuropathy
Author(s) -
Pastore Carlos,
Marhuenda Dolores,
Marti Juan,
Cardona Antonio
Publication year - 1994
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880170904
Subject(s) - sural nerve , nerve conduction velocity , nerve conduction , medicine , median nerve , compound muscle action potential , anesthesia , snap , peripheral neuropathy , sensory nerve , normal values , sensory system , anatomy , electrophysiology , endocrinology , psychology , neuroscience , diabetes mellitus , computer graphics (images) , computer science
Abstract n ‐Hexane neuropathy was studied in 20 workers exposed for prolonged periods to this solvent, and with urinary 2, 5‐hexanedione concentrations exceeding the biological exposure index recommended by the American Conference of Governmental Industrial Hygienists (5 mg/L) with a mean of 11.02 mg/L (range 5.3—24.2 mg/L). Although neurological examination did not detect significant anomalies in any of the patients, and the conduction velocity and F waves of all the nerves tested were normal, neurographic studies revealed significant differences in the amplitude of sensory nerve action potentials (SNAP) recorded from the sural (mean 14.0 μV), median (mean 17.3 μV), and ulnar (mean 7.9 μV) nerves when compared with normal values from healthy adults of the same age range, examined under identical conditions. The amplitude of the SNAP in sural and median nerves correlated significantly with the number of years worked. The notable decrease in mean amplitude of the SNAP appeared to reflect the primary neurotoxic effects of 2,5‐hexanedione. © 1994 John Wiley & Sons, Inc.