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Postexercise phosphocreatine resynthesis is slowed in multiple sclerosis
Author(s) -
KentBraun Jane A.,
Sharma Khema R.,
Miller Robert G.,
Weiner Michael W.
Publication year - 1994
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880170802
Subject(s) - phosphocreatine , isometric exercise , medicine , skeletal muscle , endocrinology , deconditioning , stimulation , oxidative phosphorylation , multiple sclerosis , chemistry , energy metabolism , biochemistry , psychiatry
To determine whether skeletal muscle oxidative metabolism is impaired in multiple sclerosis (MS), 31 phosphorus magnetic resonance spectroscopy was used to measure the rate of intramuscular phosphocreatine (PCr) resynthesis following exercise in MS and controls. Thirteen MS patients underwent intermittent isometric tetanic contractions of the dorsiflexor muscles elicited by stimulation of the peroneal nerve. Eight healthy control subjects performed voluntary isometric exercise of the same muscles. During exercise, there were no differences between groups in the fall of either PCr or pH. However, the half‐time ( T ‐ 1/2 ) of PCr recovery following exercise was significantly longer in MS (2.3 ± 0.3 min) compared to controls (1.2 ± 0.1 min, P < 0.02). These data provide evidence of slowed PCr resynthesis following exercise in MS, which indicates impaired oxidative capacity in the skeletal muscle of this group. This finding suggests that intramuscular changes consistent with deconditioning may be important in the altered muscle function of persons with MS. © 1994 John Wiley & Sons, Inc.