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Pathogenesis of axonal Guillain–Barré syndrome: Hypothesis
Author(s) -
Yuki Nobuhiro
Publication year - 1994
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880170619
Subject(s) - chromatolysis , acute motor axonal neuropathy , pathogenesis , axon , guillain barre syndrome , neuroscience , motor neuron , antibody , motor nerve , medicine , biology , immunology , spinal cord
Pathologic studies of acute motor axonal neuropathy show strong evidence of the presence of primary axonal Guillain–Barré syndrome (GBS). The pathogenesis of axonaf GBS is speculated to be as follows: (1) Infection by an organism induces the high production of a crossreactive antibody between an infectious agent and the motor nerve axon in patients with a particular immunogenetic background. (2) The antineural antibody binds to the motor nerve terminals, thereby inhibiting motoneuron excitability and causing muscular weakness. (3) Binding of the antineural antibody, or subsequent functional impairment of the motoneurons, causes the motor axon to degenerate from the terminals. (4) In severe cases, extensive axonal loss and central chromatolysis of the motoneurons occur. These inhibit recovery and lead to a poor functional prognosis. © 1994 John Wiley & Sons, Inc.

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