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Anionic phospholipids calcium binding sites in Duchenne and murine X‐linked muscular dystrophy
Author(s) -
Moggio Maurizio,
Prelle Alessandro,
Fagiolari Gigliola,
Checcarelli Nicoletta,
Sciacco Monica,
Ciscato Patrizia,
Scarlato Guglielmo
Publication year - 1994
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880170503
Subject(s) - duchenne muscular dystrophy , dystrophin , muscular dystrophy , itga7 , mdx mouse , pathogenesis , utrophin , necrosis , myocyte , calcium , myopathy , biology , endocrinology , medicine , chemistry , microbiology and biotechnology
Duchenne muscular dystrophy (DMD) and murine X‐linked muscular dystrophy (mdx) are genetically homologous and both characterized by absence of dystrophin. The function of this protein is not defined nor is the pathogenesis of the severe muscle necrosis and progressive weakness found in DMD but not in mdx. Recently we found that anionic phospholipid (AP) calcium binding sites are lacking at the muscle cell surface in DMD and we correlated these data with dystrophin deficiency and muscle necrosis. In order to verify the role of AP lack in the pathogenesis of muscle necrosis in DMD we studied the ultrastructural localization of these Ca ++ receptors in mdx muscle membrane showing that they are normally represented as they are in control mouse and normal human muscle. The absence of AP in DMD compared with a normal distribution in mdx suggests that these calcium binding site alterations play an important and specific role in muscle fiber necrosis. © 1994 John & Sons, Inc.