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X‐linked bulbospinomuscular atrophy (Kennedy's disease) masquerading as lead neuropathy
Author(s) -
Albers James W.,
Bromberg Mark B.
Publication year - 1994
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880170409
Subject(s) - medicine , atrophy , denervation , muscle cramp , weakness , spinal and bulbar muscular atrophy , gynecomastia , muscle atrophy , amyotrophy , surgery , androgen receptor , prostate cancer , cancer
A 43‐year‐old male was referred by a veterinarian who evaluated his dog for a seizure and suspected a toxic lead exposure for both. He refurbished houses, removing old paint, and complained of decreased cognition, fatigue, and muscle cramps. He had a depressed affect, postural tremor, right arm weakness with partial denervation on EMG, and borderline‐low sensory nerve action potential (SNAP) amplitudes. A mild anemia and elevated serum and urine lead levels supported a diagnosis of lead neuropathy. Chelation therapy increased urine lead excretion without symptomatic improvement. His brother worked part‐time with him and developed similar findings, but also had difficulty chewing, dysphagia, perioral twitching, gynecomastia, and multifocal denervation of extremity and facial muscles. His lead levels were not elevated, but an androgen receptor mutation identified on the X chromosome for both brothers confirmed the diagnosis of X‐linked bulbospinomuscular atrophy (Kennedy's disease). © 1994 John Wiley & Sons, Inc.