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Widenings of the myelin lamellae in a typical Guillain–Barré syndrome
Author(s) -
Vallat J. M.,
Leboutet M. J.,
Jauberteau M. O.,
Tabaraud F.,
Couratier P.,
Akani F.
Publication year - 1994
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880170403
Subject(s) - myelin , myelin sheath , guillain barre syndrome , pathology , sural nerve , peripheral nerve , peripheral neuropathy , medicine , immunofluorescence , monoclonal antibody , chemistry , anatomy , biology , immunology , neuroscience , antibody , central nervous system , endocrinology , diabetes mellitus
The so‐called “widenings of the myelin lamellae” are thought to be specific ultrastructural features of peripheral nerve myelin in patients with peripheral neuropathy associated with a monoclonal dysglobulinemia of IgM type and antiglycolipid activity. We report here a case of Guillain–Barré syndrome with no evidence of serum monoclonal dysglobulinemia, presenting the typical widenings of the myelin lamellae in small‐diameter myelinated fibers from a sural nerve biopsy. In view of the positive reaction with anti‐C3d complement on direct immunofluorescence, an immunological mechanism may be involved in the widenings of the myelin lamellae. © 1994 John Wiley & Sons, Inc.