Widenings of the myelin lamellae in a typical Guillain–Barré syndrome | Zendy

Vallat J. M. | Zendy; Leboutet M. J. | Zendy; Jauberteau M. O. | Zendy; Tabaraud F. | Zendy; Couratier P. | Zendy; Akani F. | Zendy

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Widenings of the myelin lamellae in a typical Guillain–Barré syndrome

Author(s) -

Vallat J. M.,

Leboutet M. J.,

Jauberteau M. O.,

Tabaraud F.,

Couratier P.,

Akani F.

Publication year - 1994

Publication title -

muscle and nerve

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.025

H-Index - 145

eISSN - 1097-4598

pISSN - 0148-639X

DOI - 10.1002/mus.880170403

Subject(s) - myelin , myelin sheath , guillain barre syndrome , pathology , sural nerve , peripheral nerve , peripheral neuropathy , medicine , immunofluorescence , monoclonal antibody , chemistry , anatomy , biology , immunology , neuroscience , antibody , central nervous system , endocrinology , diabetes mellitus

The so‐called “widenings of the myelin lamellae” are thought to be specific ultrastructural features of peripheral nerve myelin in patients with peripheral neuropathy associated with a monoclonal dysglobulinemia of IgM type and antiglycolipid activity. We report here a case of Guillain–Barré syndrome with no evidence of serum monoclonal dysglobulinemia, presenting the typical widenings of the myelin lamellae in small‐diameter myelinated fibers from a sural nerve biopsy. In view of the positive reaction with anti‐C3d complement on direct immunofluorescence, an immunological mechanism may be involved in the widenings of the myelin lamellae. © 1994 John Wiley & Sons, Inc.

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