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Muscle pain: Animal and human experimental and clinical studies
Author(s) -
Marchettini Paolo
Publication year - 1993
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880161006
Subject(s) - nociceptor , medicine , sensation , neuroscience , physical medicine and rehabilitation , mononeuropathy , nociception , sensory system , afferent , delayed onset muscle soreness , anatomy , psychology , muscle damage , peripheral neuropathy , receptor , endocrinology , diabetes mellitus
The search for the identification of the sensory apparatus encoding muscle pain sensation in humans is recounted. Basic neurophysiologic animal studies, leading to a description of slowly conducting afferent from muscle and definition of high threshold polymodal muscle nociceptors, and pioneer psychophysic human studies together with recent microneurographic experiments in humans are described. The phenomena of muscle pain broad localization and distant referral are discussed, and clinical implications are extrapolated to interpret muscle pain as a localizing sign of mononeuropathy or radiculopathy. The identification of human muscle nociceptors has defined the scientific standard to test emerging clinical descriptions having muscle pain as a symptom. © 1993 John Wiley & Sons, Inc.