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Hereditary motor–sensory neuropathy and movement disorders
Author(s) -
Cardoso Francisco E. C.,
Jankovic Joseph
Publication year - 1993
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880160904
Subject(s) - essential tremor , parkinsonism , hereditary motor and sensory neuropathy , movement disorders , medicine , dystonia , family history , physical medicine and rehabilitation , postural tremor , neurological disorder , peripheral neuropathy , intention tremor , central nervous system disease , psychiatry , disease , ataxia , diabetes mellitus , endocrinology
To explore the relationship between hereditary motor and sensory neuropathy (HMSN) and movement disorders, we examined 7 patients with HMSN referred to our Movement Disorders Clinic and surveyed members of the Charcot‐Marie‐Tooth association. The following movement disorders were observed in the index patients: postural tremor in 6, rest tremor in 3, and Parkinsonism and dystonia in 2. Tremor, present in 40% of the 201 patients who responded to the survey, was first noted at a mean age of 36 years, and mostly involved the hands. Family history of tremor was more frequent in the tremor group ( P > 0.005), which also had a significantly worse writing score than the nontremor group ( P > 0.001). The overlap in clinical features between HMSN‐associated tremor and essential tremor (ET), the high frequency of family history of tremor, and the lack of a relationship between the severity of tremor and of peripheral neuropathy suggest that the tremor in HMSN is pathogenically related to ET. © 1993 John Wiley & Sons, Inc.