Premium
Modification of the peripheral nerve disturbance in ciguatera poisoning in rats with lidocaine
Author(s) -
Cameron John,
Flowers Andrew E.,
Capra Michael F.
Publication year - 1993
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880160714
Subject(s) - ciguatera , lidocaine , medicine , ciguatoxin , peripheral nerve , disturbance (geology) , anesthesia , neuroscience , anatomy , biology , fish <actinopterygii> , fishery , paleontology
Electrophysiological studies were performed on the ventral tail nerve of adult rats following intraperitoneal injection of a crude extract of ciguatoxin from known toxic fish flesh. Ciguatoxin induced significant slowing of both mixed and motor nerve conduction velocities and also significant reductions in both motor and mixed nerve amplitudes. Both absolute and supernormal periods were significantly prolonged together with an increase in the magnitude of the supernormal response. These electrophysiological disturbances were modified or blocked by intraperitoneal lidocaine. These findings suggest that lidocaine may have a potential therapeutic application in the treatment of the neurological disturbance in acute ciguatera poisoning in humans.