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Immunohistochemical characteristics of polymyositis in patients with HTLV‐1–associated myelopathy and HTLV‐I carriers
Author(s) -
Higuchi Itsuro,
Montemayor Elizabeth S.,
Izumo Syuji,
Inose Masaru,
Osame Mitsuhiro
Publication year - 1993
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880160507
Subject(s) - polymyositis , immunohistochemistry , medicine , antigen , myelopathy , immunology , myositis , immune system , pathology , spinal cord , psychiatry
The immunohistochemical characteristics of polymyositis in patients with HTLV‐I‐associated myelopathy (HAM) and HTLV‐I carriers were studied. Infiltrating cells were predominantly T cells and were not different from in the control group. All specimens contained positively staining muscle fibers for MHC class I antigens, but class II antigens were also expressed in some muscle fibers in 1 patient with HTLV‐I‐negative polymyositis, 3 patients with HTLV‐I‐positive polymyositis, and all 5 HAM patients with polymyositis. Expression of the neural cell adhesion molecule was lowest in the HAM patients. These findings may suggest a different immune environment in polymyositis with HAM. © 1993 John Wiley & Soncs, Inc.