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An experimental model of mitochondrial myopathy: Germanium‐induced myopathy and coenzyme Q 10 administration
Author(s) -
Wu ChienMing,
Matsuoka Taro,
Takemitsu Masakazu,
Goto YuIchi,
aka Ikuya
Publication year - 1992
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880151107
Subject(s) - mitochondrial myopathy , mitochondrial encephalomyopathy , cytochrome c oxidase , myopathy , rotenone , coenzyme q – cytochrome c reductase , mitochondrion , coenzyme q10 , mitochondrial respiratory chain , respiratory chain , reductase , cytochrome , chemistry , biochemistry , cytochrome c , medicine , endocrinology , biology , enzyme , mitochondrial dna , gene
In skeletal muscles from rats treated with germanium for 23 weeks, there were numerous ragged‐red fibers and cytochrome‐ c oxidase (COX)‐deficient fibers. Biochemically, germanium reduced the enzyme activities in the mitochondrial respiratory chain. Rotenone‐sensitive NADH–cytochrome‐ c reductase as well as COX activities were markedly reduced, while succinate–cytochrome‐ c reductase was less severely, but significantly, affected. The histopathological findings in these muslces were similar to those seen in patients with mitochondrial encephalomyopathy, suggesting that germanium‐induced myopathy may be a useful experimental model. Coenzyme Q 10 administration appeared to be ineffective in preventing this experimental myopathy. © 1992 John Wiley & Sons, Inc.
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