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Demyelinating peripheral neuropathy in Creutzfeldt–Jakob disease
Author(s) -
Neufeld Miriam Y.,
Josiphov Joseph,
Korczyn Amos D.
Publication year - 1992
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880151103
Subject(s) - medicine , peripheral neuropathy , disease , pathology , peripheral , prion protein , diabetes mellitus , endocrinology
We desribe 2 patients of Jewish Libyan descent, who presented with a clinical syndrome compatible with Creutzfeldt–Jakob disease and who were found to have a mutation of codon 200 in the prion protein. The patients developed symptoms and signs of peripheral nerve involvement diagnosed by electrodiagnostic and histopathological studies as demyelinating neuropathy. This may be a rare manifestation of Creutzfeldt–Jakob disease. © 1992 John Wiley & Sons, Inc.