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Vasculitic neuropathy in a patient with cryoglobulinemia and anti‐MAG IGM monoclonal gammopathy
Author(s) -
Thomas Florian P.,
Lovelace Robert E.,
Ding XinSheng,
Sadiq Saud A.,
Petty George W.,
Sherman William H.,
Latov Norman,
Hays Arthur P.
Publication year - 1992
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880150805
Subject(s) - mononeuritis multiplex , pathology , medicine , cryoglobulinemia , sural nerve , cryoglobulins , nerve biopsy , vasculitis , cryoglobulin , myelin , polyneuropathy , gammopathy , antibody , monoclonal , immunology , monoclonal antibody , peripheral neuropathy , disease , hepatitis c virus , virus , endocrinology , diabetes mellitus , central nervous system
A patient with sensorimotor mononeuritis multiplex had a type II cryoglobulin with an IgM kappa M‐protein that appeared to contain monoclonal anti‐MAG antibodies of the same isotype. A sural nerve biopsy demonstrated necrotizing arteritis and features of both axonal degeneration and demyelination. IgM kappa and C3 deposits were present on the myelin sheath of some residual nerve fibers. The findings suggest that the anti‐MAG antibodies contributed to the myelin damage, while cryoprecipitates may have caused the vasculitis and axonal degeneration. © 1992 John Wiley & Sons, Inc.