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Twitch and tetanus in mdx mouse muscle
Author(s) -
Quinlan John G.,
Johnson Scott R.,
McKee Mari K.,
Lyden Sean P.
Publication year - 1992
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880150713
Subject(s) - mdx mouse , tetanus , skeletal muscle , tibialis anterior muscle , long term potentiation , medicine , muscle fatigue , duchenne muscular dystrophy , muscle contraction , anatomy , chemistry , endocrinology , biology , physical medicine and rehabilitation , dystrophin , electromyography , immunology , vaccination , receptor
We compared mdx and C57BL10 anterior tibial muscle force in situ (single pulse, multiple pulse, staircase, posttetanic potentiation, and fatiguing stimulation patterns) to define muscle strength, physiology, and fatigue resistance. The relatively hypertrophied mdx muscle showed: reduced strength (N/cm 2 ), an increased twitch‐tetanus ratio, and resistance to postfatigue twitch slowing. These differences implicate altered mdx calcium regulation, and emphasize the importance of measuring both muscle function and morphology in mdx treatment trials. © 1992 John Wiley & Sons, Inc.