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McArdle's disease and gout
Author(s) -
Puig Juan G.,
de Miguel Eugenio,
Mateos Felícitas A.,
Miranda Ma Eugenia,
Romera Nuria M.,
Espinosa Ana,
Gijón Juan
Publication year - 1992
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880150711
Subject(s) - gout , uric acid , hypoxanthine , xanthine , purine metabolism , purine , endocrinology , medicine , urine , urinary system , hyperuricemia , chemistry , excretion , nucleotide , adenine nucleotide , biochemistry , enzyme , gene
We report the first case of McArdle's disease (muscle phosphorylase deficiency) and tophaceous gout. To examine the contribution of adenine nucleotide degradation to the disturbance of uric acid metabolism, we labeled the adenine nucleotide pool with [8‐ 14 C]adenine, and measured plasma and urine purines following vigorous exercise tests. Plasma and urinary hypoxanthine and xanthine concentrations and the specific radioactivity of urinary purines increased markedly, but plasma urate levels and uric acid excretion were not substantially modified. We suggest that, in this patient, the association of McArcle's disease with gout is coincidental. © 1992 John Wiley & Sons, Inc.