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Changes in mast‐cell distribution in skeletal muscle after denervation
Author(s) -
SánchezMejorada Gabriela,
AlonsodeFlorida Francisco
Publication year - 1992
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880150615
Subject(s) - denervation , anatomy , skeletal muscle , tendon , biology , contraction (grammar) , mast cell , neuromuscular transmission , motor neuron , muscle contraction , neuroscience , medicine , endocrinology , spinal cord , immunology
Motor nerves are known to govern the structure of skeletal muscle. In the normal guniea pig diaphragmatic muscle, we found that mast cells were predominatly located in the central tendon. Following denervation, these cells became more numerous in the muscle itself than in the tendon. There fore, nervous trophic influences are exerted on other tissue elements besides those which sustain transmission and contraction. Ascertaining mastcell distribution in biopsies may help to elucidate denervation effects in motor neuron diseases.