Premium
Motor‐evoked responses in primary lateral sclerosis
Author(s) -
Brown W. F.,
Ebers G. C.,
Hudson A. J.,
Pringle C. E.,
Veitch J.
Publication year - 1992
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880150515
Subject(s) - amyotrophic lateral sclerosis , anterior horn cell , somatosensory evoked potential , neuroscience , electrophysiology , medicine , denervation , motor neuron , upper motor neuron , somatosensory system , multiple sclerosis , electromyography , nerve conduction velocity , anatomy , psychology , spinal cord , pathology , disease , psychiatry
Primary lateral sclerosis (PLS) may be distinguished on the basis of clinical and pathological features from amyotrophic lateral sclerosis (ALS). The former is featured by a much longer clinical course, exclusively upper motor neuron findings, losses of precentral pyramidal neurons, and preservation of anterior horn cells. Electrophsiological studies of 7 PLS cases have shown normal peripheral motor conduction, absent or very delayed motor‐evoked poteintials, the occasional late development of denervation activity in distal muscles, and normal somatosensory‐evoked potentials.