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Denervation increases clenbuterol sensitivity in muscle from young rats
Author(s) -
Maltin Charlotte A.,
Delday Margaret I.,
Hay Susan M.,
Baillie Andrew G. S.
Publication year - 1992
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880150210
Subject(s) - clenbuterol , denervation , wasting , muscle hypertrophy , atrophy , medicine , endocrinology , muscle atrophy , dose , muscle fibre , skeletal muscle
Clenbuterol has been shown to ameliorate denervation‐induced atrophy and, therefore, clearly has therapeutic potential in the treatment of muscle wasting conditions in man. Previous studies have used dosages in rats which would be unacceptable in clinical practice, but the present results show that denervated muscle has a greater sensitivity to the drug than innervated or cardiac muscle. Fiber hypertrophy and an increase in protein and RNA content could be observed in denervated muscles but not in innervated muscles at a dose of 10 μg/kg body weight. When considered on a metabolic body weight basis, the effective dose in rats and the "safe" dose in man are surprisingly comparable. The observations imply that there is good reason to suppose that clenbuterol could be effective in ameliorating similar wasting conditions in man.