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Absence of malignant hyperthermia contractures in Becker‐Duchenne dystrophy at age 2
Author(s) -
Gronert Gerald A.,
Fowler William,
Cardinet George H.,
Grix Arthur,
Ellis William G.,
Schwartz Marshall Z.
Publication year - 1992
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880150110
Subject(s) - malignant hyperthermia , medicine , muscle biopsy , contracture , muscle contracture , rhabdomyolysis , hypermetabolism , dystrophy , myopathy , duchenne muscular dystrophy , concomitant , biopsy , anesthesia , muscular dystrophy , joint contracture , surgery , pathology
Two 2‐year‐old males underwent muscle biopsy that established the histopathologic diagnosis of Becker dystrophy in one, and Duchenne dystrophy in the other. Concomitant contracture testing with caffeine or halothane was normal for malignant hyperthermia (MH). The results suggest that acute hypermetabolism or acute rhabdomyolysis during anesthesia, in patients with these disorders, is related to the X‐linked myopathy and its associated muscle deterioration, rather than to the autosomal dominant MH.