Premium
Autonomic function in hereditary motor and sensory neuropathy (charcot‐marie‐tooth disease)
Author(s) -
Ingall Timothy J.,
McLeod James G.
Publication year - 1991
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880141107
Subject(s) - hereditary motor and sensory neuropathy , medicine , reflex , tooth disease , sensory system , autonomic neuropathy , disease , degeneration (medical) , autonomic function , peripheral neuropathy , peripheral , heart rate , cardiology , blood pressure , pathology , heart rate variability , neuroscience , psychology , endocrinology , diabetes mellitus , biology , genetics , cell culture , neuroblastoma
Autonomic tests of heart rate and blood pressure control using both invasive and noninvasive techniques were performed on 11 patients with hereditary motor and sensory neuropathy (HMSN) types 1, and 4 patients with HMSN type 2. The results were compared with those of 76 control subjects. No significant difference was found between the patient and control groups. Impairment of sweating on the extremities was found in patients with HMSN types 1 and 2, consistent with distal degeneration of sympathetic fibers in peripheral nerves, but there were no abnormalities of cardiovascular reflex control mechanisms.