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Human peripheral nerve sheath neoplasm: Expression of Schwann cell‐related markers and their relation to malignant transformation
Author(s) -
Yasuda Takeshi,
Sobue Gen,
Ito Takayuki,
Doyu Manabu,
Sugiura Isao,
Hashizume Yoshio,
Kato Kanefusa
Publication year - 1991
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880140903
Subject(s) - endoneurium , galactocerebroside , schwann cell , pathology , neurofibroma , glial fibrillary acidic protein , malignant transformation , sural nerve , nerve growth factor , peripheral nervous system , biology , medicine , receptor , anatomy , immunohistochemistry , neurofibromatosis , peripheral nerve , myelin , central nervous system , oligodendrocyte
We immunohistochemically examined the expression of Schwann cellrelated markers, nerve growth factor (NGF) receptor, S‐100 α‐ and b̃‐proteins, glial fibrillary acidic protein (GFAP), and galactocerebroside (gal C) in 5 malignant schwannomas, 21 benign peripheral nerve sheath tumors, and 4 apparently normal sural nerves. NGF receptor was expressed in the malignant schwannomas and benign peripheral nerve sheath tumors, but not in the endoneurium of apparently normal peripheral nerves. S‐100 α‐protein was observed in malignant schwannomas and in some neurofibroma cells. All cases were strongly positive for S‐100 b̃‐protein but were negative for GFAP and gal C. Our results suggest that these Schwann cell‐related markers may be useful in identifying peripheral nerve sheath neoplasms as well as their malignant transformation.