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Type 2 fiber predominance in lambert–eaton myasthenic syndrome
Author(s) -
Squier Marian,
Chalk Colin,
HiltonJones David,
Mills Kerry R.,
NewsomDavis John
Publication year - 1991
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880140705
Subject(s) - lambert eaton myasthenic syndrome , fiber type , medicine , atrophy , myasthenia gravis , skeletal muscle
Serial muscle biopsies in a noncarcinomatous case of Lambert–Eaton myasthenic syndrome (LEMS) have shown progressive atrophy and loss of type 1 fibers, resulting in overwhelming type 2 predominance. A similar abnormality was found in a single biopsy from a second case of LEMS without associated carcinoma. Review of the literature suggests that type 2 fiber predominance has been observed in at least one other biopsied case. Interference with transmitter release caused by anti–voltage‐gated calcium channel antibodies may deprive type 1 muscle fibers of the low frequency discharge necessary to maintain their metabolic properties.