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Expression of heat shock protein epitopes in tubular aggregates
Author(s) -
Martin Joanne E.,
Mather Kanti,
Swash Michael,
Gray Alan B.
Publication year - 1991
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880140304
Subject(s) - heat shock protein , epitope , cytoskeleton , shock (circulatory) , hsp70 , pathogenesis , chemistry , microbiology and biotechnology , protein aggregation , pathology , antibody , biophysics , biology , biochemistry , medicine , immunology , cell , gene
Abstract Tubular aggregates may be found in a variety of conditions and have been associated with a wide range of chemical and ischemic insults. We report clinical and histological features in a case of myopathy with tubular aggregates. The structure of these tubular aggregates was examined using antibodies to cytoskeletal proteins and heat shock proteins. Epitopes of the 72 kD heat shock protein were expressed in the areas of abnormality in this case and in a case of hypokalemic periodic paralysis with tubular aggregates. Heat shock proteins have a role in the modulation of the tertiary structure of proteins and may be involved in the pathogenesis of tubular aggregates and other microtubular abnormalities in muscle.