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Early myelin lesions in experimental allergic neuritis
Author(s) -
Rosen Janet L.,
Brown Mark J.,
Hickey William F.,
Rostami Abdolmohammad
Publication year - 1990
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880130712
Subject(s) - neuritis , myelin , macrophage , medicine , pathology , immunology , edema , central nervous system , biology , surgery , biochemistry , in vitro
We examined the evolution of demyelination in spinal roots of Lewis rats immunized with whole nerve and complete Freund' adjuvant. Roots were morphologically normal until 11 days after immunization, when we found endoneurial edema and myelin vesiculation in the absence of mononuclear cell contacts. Macrophage‐associated myelin stripping was not detected until day 12. Macrophage infiltrations were extensive by day 14, but lymphocytes were sparse. These observations indicate that in experimental allergic neuritis, myelin injury may occur before macrophage‐mediated demyelination, and provide support for an early role of serum factors in the development of this disorder.