Premium
Muscle biopsy in AIDS and ARC: Analysis of 50 patients
Author(s) -
Gabbai Alberto A.,
Schmidt Beny,
Castelo Adauto,
Oliveira Acary S. B.,
Lima Jose G. C.
Publication year - 1990
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880130611
Subject(s) - atrophy , muscle biopsy , pathology , medicine , arc (geometry) , biopsy , muscle fibre , necrosis , anatomy , skeletal muscle , geometry , mathematics
We report a large spectrum of histological muscle abnormalities in 50 homosexual men with AIDS and ARC. We encountered moth‐eaten fibers in 76%, angulated fibers in 76%, type groupings in 62%, type 2 fiber atrophy in 58%, mononuclear endomysial and/or perivascular in filtrates in 36%, necrosis and phagocytosis in 30%, and target fibers in 6%. Two patients showed vasculitis and two others showed perifascicular atrophy. On the whole, 96% of the biopsies showed substantial abnormalities. Muscle involvement in AIDS seems more common than previously suspected.