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Effect of clenbuterol on normal and denervated muscle growth and contractility
Author(s) -
Agbenyega Edward Tsiri,
Wareham Anthony Clive
Publication year - 1990
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880130305
Subject(s) - clenbuterol , medicine , contractility , endocrinology , muscle hypertrophy , anabolism , wasting
The reported anabolic action of some β 2 agonists may have clinical applications in certain muscle wasting states. Administration of clenbuterol (2mg/kg diet for 14 days) to rats resulted in a limited degree of hypertrophy of normal muscles; the effect was more pronounced on fast‐twitch muscles than on slow‐twitch muscles. The anabolic effect was greatest in denervated muscles, where it was significantly more effective on the slow‐twitch type. Clenbuterol significantly improved the contractile properties of denervated slow‐twitch muscle, reverting them toward normal, but had little effect on contractile properties of denervated fast‐twitch muscle. Such differential effects of clenbuterol must be taken into consideration in the evaluation of any future human intervention study.