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Conduction block in neuropathies with necrotizing vasculitis
Author(s) -
Ropert Angèle,
Metral Stéphane
Publication year - 1990
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880130203
Subject(s) - mononeuropathy , medicine , vasculitis , electrophysiology , pathological , necrotizing vasculitis , nerve conduction velocity , mononeuritis multiplex , pathology , axonal degeneration , peripheral neuropathy , anatomy , disease , diabetes mellitus , endocrinology
Thirty‐two patients with a mononeuropathy multiplex associated with a systemic necrotizing vasculitis were studied. The main abnormality was a loss of motor and sensory axons confirmed by electrophysiological and histological methods. A conduction block was observed in five patients, but only one was at a usual site of compression. Based on previous pathological studies and the experimental data in human and animals, the mechanism of the block is proposed to be ischemic. It is suggested that a conduction block in one nerve in a neuropathy with two or more individual nerves affected and with electrophysiological features of axonal degeneration may be due to a vasculitis.