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Far‐field and cortical somatosensory evoked potentials in motor neuron disease
Author(s) -
Zanette Giampietro,
Polo Alberto,
Gasperini Marcella,
Bertolasi Laura,
De Grandis Domenico
Publication year - 1990
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880130110
Subject(s) - amyotrophic lateral sclerosis , earlobe , somatosensory evoked potential , motor neuron , medicine , neuroscience , upper motor neuron , motor cortex , scalp , somatosensory system , atrophy , lower motor neuron , psychology , disease , anatomy , pathology , stimulation
Abstract We examined median somatosensory evoked potentials (SEPs) in 26 patients with sporadic motor neuron disease (MND). SEPs were recorded with multiple scalp derivations, using both the midfront and the earlobe as references for each subject. Central conduction time (CCT) was abnormal in three patients, but only when using the midfront reference. Moreover, an exclusive alteration of the early prerolandic potentials potentials (absent or delayed P20 and/or P22) was noted using the earlobe reference in amyotrophic lateral sclerosis and in progressive bulbar palsy (54% and 50% of patients, respectively) but not in progressive muscular atrophy. These findings correlated with clinical evidence of upper motor neuron signs and with the severity of the disease. In agreement with recentviews regarding the sources of the early anterior cortical responses, neuronal loss in the motor cortex may be considered as affecting the generator sites of these potentials.