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Role of nerve and tension in maturation of posthatching slow‐tonic muscle in chicken
Author(s) -
Gardahaut MarieFrance C.,
Rouaud Thierry P.,
Renaud Didier,
Khaskiye Ahmad,
Le Douarin Georges H.
Publication year - 1989
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880121112
Subject(s) - denervation , tonic (physiology) , atrophy , myosin , muscle hypertrophy , medicine , anatomy , population , muscle atrophy , endocrinology , chemistry , biology , microbiology and biotechnology , environmental health
The role of motor innervation and muscle tension in the posthatching maturation of the slow‐tonic anterior latissimus dorsi (ALD) muscle of the chicken has been investigated. Modification of the muscle tension was obtained either by maintaining ALD in a shortened state or by stretching, after or without denervation. In denervated as well as in innervated ALD, shortening resulted in atrophy and inhibition of developmental change in muscle fiber population. In contrast, stretch causes hypertrophy, transformation of all 3B fibers, increase in SM 2 isomyosin expression, and decrease in Ca 2+ ‐activated myosin ATPase in innervated or denervated ALD. On the other hand oxidative activity in ALD fibers was strikingly reduced after denervation even in presence of stretch‐induced hypertrophy. This study suggests that a passive stretch can be involved in some, but not all, changes in ALD characteristics occurring after denervation and may be also involved in normal posthatching development of the slow‐tonic muscle. Possible clinical implications of these results in relation to treatments for preventing muscle atrophy resulting from immobilization or disuse are suggested.