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Immunohistochemical differential distribution of S‐100α and S‐100β in the peripheral nervous system of the rat
Author(s) -
Sugimura Kimiya,
Haimoto Hajime,
Nagura Hiroshi,
Kato Kanefusa,
Takahashi Akira
Publication year - 1989
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880121109
Subject(s) - neurofilament , beta (programming language) , endoplasmic reticulum , alpha (finance) , peripheral nervous system , cytoplasm , dorsal root ganglion , biology , nucleus , immunohistochemistry , central nervous system , anatomy , pathology , neuroscience , spinal cord , microbiology and biotechnology , medicine , immunology , construct validity , nursing , patient satisfaction , computer science , programming language
The localization of the α subunit of the S‐100 protein (S‐100α) and β subunit (S‐100β) was studied in the peripheral nervous system of the rat. In peripheral nerves, S‐100α and S‐100β were found in the cytoplasm of Schwann cells. Axons were positively stained in part by S‐100α and almost totally by S‐100β. In the dorsal root ganglia, S‐100β was found in satellite cells and their processes and in some neurons. S‐100β was found in more of the large neurons, but almost all of the small neurons were negative for S‐100β. In the anterior horn cells, S‐100β staining was stronger than that of S‐100β. In Schwann cells, both S‐100β and S‐100β were present on the rough endoplasmic reticulum, free ribosomes, and nucleus, as seen by electron microscopy. The S‐100α and S‐100β in axons were associated with microtubules and neurofilaments.