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Recurrent myoglobinuria and HIV seropositivity: Incidental or pathogenic association?
Author(s) -
Younger David S.,
Hays Arthur P.,
Uncini Antonio,
Lange Dale J.,
Lovelace Robert E.,
DiMauro Salvatore
Publication year - 1989
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.880121009
Subject(s) - myoglobinuria , polymyositis , medicine , asymptomatic , muscle biopsy , creatine kinase , muscle weakness , rhabdomyolysis , weakness , biopsy , immunology , surgery
There have been few cases of polymyositis in patients with AIDS, and polymyositis is rarely a cause of myoglobinuria. We studied a 20‐year‐old homosexual man with recurrent myoglobinuria. He was asymptomatic between episodes. Each episode was accompanied by muscle pain, limb weakness, high serum levels of creatine kinase, and pigmenturia. Muscle biopsy showed active necrosis without inflammation or abnormalities of glycolytic or other energy‐generating enzymes. Antibodies to HIV were present in serum. Clinical evidence of AIDS has not developed in 2 years. Recurrent myoglobinuria may be another consequence of HIV infection.